2. Signaling Pathways
  3. Immunology/Inflammation
  4. PGE synthase

PGE synthase

Prostaglandin E synthase

PGE synthase

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PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) to PGE2, is known to comprise a group of at least three structurally and biologically distinct enzymes. There are membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).

mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX-1. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. cPGES is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE2 production.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N8458
    Cryogenine
    		Inhibitor
    Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.
    Cryogenine
  • HY-N6257R
    Cafestol (Standard)
    		Inhibitor
    Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer.
    Cafestol (Standard)
  • HY-130356
    5-trans U-46619
    		Inhibitor
    5-trans U-46619 is a PGE synthase inhibitor. At a concentration of 10 μM, 5-trans U-46619 inhibits PGE synthase by <20%.
    5-trans U-46619
  • HY-169858
    Prostaglandin E2 Inhibitor 3
    		Inhibitor
    Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50 = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice.
    Prostaglandin E2 Inhibitor 3
  • HY-137157
    Suprofen L-lysine
    		Inhibitor
    Suprofen L-lysine (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).
    Suprofen L-lysine
  • HY-164358
    α-Gracinoic acid
    		Inhibitor
    α-Gracinoic acid is an mPGES-1 inhibitor with anti-inflammatory activity.
    α-Gracinoic acid
  • HY-139171
    F092
    		Inhibitor 99.79%
    F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a KD value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses.
    F092
  • HY-122064
    FR20
    		Inhibitor
    FR20 acts as an inhibitor of human microsomal prostaglandin synthase 1 (mPGES 1).
    FR20
  • HY-118184
    AF3485
    		Inhibitor
    AF3485 is a human mPGES-1 inhibitor that exhibits antitumor activity in vitro and in vivo. AF3485 inhibits tumor-associated angiogenesis by reducing PGE2 production, inhibiting EGFR signaling, and decreasing VEGF and FGF-2 expression. AF3485 reduced tumor growth in mice bearing human A431 xenograft tumors by subchronic administration.
    AF3485
  • HY-15123R
    (S)-Flurbiprofen (Standard)
    		Inhibitor
    (S)-Flurbiprofen (Standard) is the analytical standard of (S)-Flurbiprofen. This product is intended for research and analytical applications. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.
    (S)-Flurbiprofen (Standard)
  • HY-13475
    mPGES1-IN-8
    		Inhibitor
    mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor.
    mPGES1-IN-8
  • HY-N12643
    Gingerdione
    		Inhibitor
    [6]-Gingerdione is a prostaglandin synthesis inhibitor that can be isolated from ginger rhizomes.
    Gingerdione
  • HY-120581
    ML388
    		Inhibitor
    ML388 is a potent and selective hydroxyprostaglandin dehydrogenase (HPGD) inhibitor with an IC50 of 34 nM. ML388 induces PGE2 production in A549 cells and LNCaP prostate cancer cells.
    ML388
  • HY-B0270R
    Suprofen (Standard)
    		Inhibitor
    Suprofen (Standard) is the analytical standard of Suprofen. This product is intended for research and analytical applications. Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).
    Suprofen (Standard)
  • HY-B0890A
    Zomepirac
    		Inhibitor
    Zomepirac (McN-2783-21-98) is a potent prostaglandin biosynthesis inhibitor. Zomepirac is a non-steroidal anti-inflammatory drug (NSAID). Zomepirac can cause immune-mediated liver injury.
    Zomepirac
  • HY-W587743
    N1-Acetyl-5-methoxykynuramine hydrochloride
    		Inhibitor
    N1-Acetyl-5-methoxykynuramine (AMK) hydrochloride is an active metabolite of the neurohormone melatonin (HY-B0075). N1-Acetyl-5-methoxykynuramine hydrochloride (200 µM) effectively scavenges singlet oxygen (ROS).1 It also inhibits the production of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) induced by epinephrine and arachidonic acid in a concentration- and time-dependent manner, and suppresses the increase in COX-2 levels induced by LPS (HY-D1056) in RAW 264.7 macrophages at a concentration of 500 µM. In a mouse model of Parkinson's disease induced by MPTP (HY-15608), N1-Acetyl-5-methoxykynuramine hydrochloride (20 mg/kg) reduces the increase in lipid peroxidation in the cytosol and mitochondria of the substantia nigra and striatum. N1-Acetyl-5-methoxykynuramine hydrochloride can be used in research on metabolic and neurological diseases
    N1-Acetyl-5-methoxykynuramine hydrochloride
  • HY-30235
    Benzydamine
    Benzydamine is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells.
    Benzydamine
  • HY-B0336R
    Pranoprofen (Standard)
    		Inhibitor
    Pranoprofen (Standard) is the analytical standard of Pranoprofen. This product is intended for research and analytical applications. Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
    Pranoprofen (Standard)
  • HY-B0683S
    Limaprost-d3
    		Agonist
    Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].
    Limaprost-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity